Ten Mile Creek — is a 3rd order stream that has a drainage area of 338 square miles. Ten Mile Creek begins in South Franklin Township, Washington County and drains east for approximately 12 miles, serving as the north eastern border between Washington and Greene County, and eventually empties into the Monongahela River at Millsboro. The PADEP has classified this stream as a Trout Stocked Fishery (TSF) from the source to convergence with South Fork Ten Mile Creek and a Warm Water Fishery (WWF) from South Fork Ten mile Creek to the mouth. According to PADEP’s Internet website, no TMDLs have been approved for Ten mile Creek (PADEP, 2005). The Pennsylvania Fish and Boat Commission (PFBC) has officially approved this stream (from S.R.18 downstream to S.R. 19) as “approved trout waters”, indicating that they meet criteria qualifying them to be stocked with trout by the PFBC. These waters are closed for all fishing from March 1 to 8:00 a.m. on opening day of trout season.

Ten Mile Creek watershed has an existing watershed association titled Ten Mile Creek Watershed Conservancy. The watershed association’s slogan is as follows: “A voice for the natural continuum of Ten Mile (Cusutha's) Creek and neighboring watersheds in Greene and Washington Counties, Pennsylvania “Caring about the places no one is saving.”